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Last updated: 2022/5/22

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IL7R (Human) Recombinant Protein BioActive

  • Catalog # : P6768
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  • Specification
  • Product Description:
  • Human IL7R (NP_002176.2, 21 a.a. - 236 a.a.) partial recombinant protein with Fc and His tag at C-terminus expressed in HEK293 cells.
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 70-90
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (HEK293) expression system
  • Purification:
  • Ni-sepharose purification
  • Purity:
  • > 95% by SDS-PAGE
  • Endotoxin Level:
  • < 1.0 EU/ug
  • Activity:
  • Measured by its binding ability in a functional ELISA. Immobilized Recombinant Human IL7 at 2 ug/mL (100 uL/well) can bind Recombinant Human IL7R alpha, the EC50 of Recombinant Human IL7R alpha is 48.44 ng/mL.
  • Quality Control Testing:
  • SDS-PAGE Stained with Coomassie Blue

    QC Testing of P6768
    IL7R (Human) Recombinant Protein (Cat #P6768) was determined by SDS-PAGE with Coomassie Blue, showing a band at 70-90 kDa.
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from PBS, pH 7.4.
  • Storage Instruction:
  • Store the lyophilized protein at -20°C to -80°C for long term.
    After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Immunogen
  • SDS-PAGE
  • Application Image
  • Immunogen
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3575
  • Gene Name:
  • IL7R
  • Gene Alias:
  • CD127,CDW127,IL-7R-alpha,IL7RA,ILRA
  • Gene Description:
  • interleukin 7 receptor
  • Gene Summary:
  • The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq
  • Other Designations:
  • CD127 antigen,interleukin 7 receptor alpha chain
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