IL7R (Human) Recombinant Protein
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Specification
Product Description
Human IL7R (NP_002176.2, 21 a.a. - 236 a.a.) partial recombinant protein with Fc and His tag at C-terminus expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
70-90
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 1.0 EU/ug
Activity
Measured by the binding ability in a functional ELISA. Immobilized Recombinant Human IL7 at 2 ug/mL (100 uL/well) can bind Recombinant Human IL7R alpha, the EC50 of Recombinant Human IL7R alpha is 48.44 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
IL7R (Human) Recombinant Protein (Cat #P6768) was determined by SDS-PAGE with Coomassie Blue, showing a band at 70-90 kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — IL7R
Entrez GeneID
3575Protein Accession#
P16871-1Gene Name
IL7R
Gene Alias
CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Gene Description
interleukin 7 receptor
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq
Other Designations
CD127 antigen|interleukin 7 receptor alpha chain
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