CTLA4 (Human) Recombinant Protein
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Specification
Product Description
Human CTLA4 (NP_005205.2, 37 a.a. - 162 a.a.) partial recombinant protein with His tag at C-terminus expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
25
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 90% by SDS-PAGE
Endotoxin Level
< 1.0 EU/ug
Activity
Measured by the binding ability in a functional ELISA. Immobilized lpilimumab at 1 ug/mL (100 uL/well) can bind Recombinant Human CTLA-4 with a linear range of 6-18 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
CTLA4 (Human) Recombinant Protein (Cat #P6763) was determined by SDS-PAGE with Coomassie Blue, showing a band at 25 kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — CTLA4
Entrez GeneID
1493Protein Accession#
P16410Gene Name
CTLA4
Gene Alias
CD152, CELIAC3, CTLA-4, GSE, IDDM12
Gene Description
cytotoxic T-lymphocyte-associated protein 4
Gene Ontology
HyperlinkGene Summary
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases. [provided by RefSeq
Other Designations
OTTHUMP00000163781|cytotoxic T-lymphocyte-associated antigen 4|cytotoxic T-lymphocyte-associated serine esterase-4|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
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