CSFR3 (Human) Recombinant Protein
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Specifications
Product Description
Human CSFR3 (NP_000751.1, 25 a.a. - 621 a.a.) partial recombinant protein with His tag at C-terminus expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
90-105
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 95% by SDS-PAGE
Endotoxin Level
< 0.1 EU/ug
Activity
Measured by the ability to inhibit the GCSF-induced proliferation of M-NFS-60 mouse myelogenous leukemia lymphoblast cells.The ED50 for this effect is typically 31.5-126 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
CSFR3 (Human) Recombinant Protein (Cat #P6762) was determined by SDS-PAGE with Coomassie Blue, showing a band at 90-105 kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — CSF3R
Entrez GeneID
1441Protein Accession#
Q99062Gene Name
CSF3R
Gene Alias
CD114, GCSFR
Gene Description
colony stimulating factor 3 receptor (granulocyte)
Omim ID
138971Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the receptor for colony stimulating factor 3, a cytokine that controls the production, differentiation, and function of granulocytes. The encoded protein, which is a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variants encoding four different isoforms have been found for this gene, with three of the isoforms being membrane-bound and the other being secreted and soluble. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. [provided by RefSeq
Other Designations
CD114 antigen|OTTHUMP00000009703|OTTHUMP00000009704|OTTHUMP00000009705|colony stimulating factor 3 receptor|granulocyte colony stimulating factor receptor
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