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CD40 (Human) Recombinant Protein BioActive

  • Catalog # : P6753
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  • Specification
  • Product Description:
  • Human CD40 (NP_001241.1, 21 a.a. - 193 a.a.) partial recombinant protein with a 6×His tag at the C-terminus expressed in HEK293 cells.
  • Host:
  • Human
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (HEK293) expression system
  • Purification:
  • Ni-sepharose purification
  • Purity:
  • > 97% (determined by SDS-PAGE)
  • Endotoxin Level:
  • < 0.1 EU/ug of protein (determined by LAL method)
  • Activity:
  • Measured by its binding ability in a functional ELISA. Immobilized recombinant human CD40 at 500 ng/mL (100 uL/well) can bind recombinant human CD40 Ligand (biotinylated) with a linear range of 80-320 ng/mL.
  • Quality Control Testing:
  • SDS-PAGE Stained with Coomassie Blue

    QC Testing of P6753
  • Recommend Usage:
  • SDS-PAGE
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
  • Storage Instruction:
  • Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.
    After reconstitution with deionized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Immunogen
  • SDS-PAGE
  • Application Image
  • Immunogen
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 958
  • Gene Name:
  • CD40
  • Gene Alias:
  • Bp50,CDW40,MGC9013,TNFRSF5,p50
  • Gene Description:
  • CD40 molecule, TNF receptor superfamily member 5
  • Gene Summary:
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • B cell surface antigen CD40,B cell-associated molecule,CD40 antigen,CD40 antigen (TNF receptor superfamily member 5),CD40 type II isoform,CD40L receptor,OTTHUMP00000031699,OTTHUMP00000031700,nerve growth factor receptor-related B-lymphocyte activation mol
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