CD3E/CD3D (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
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Specification
Product Description
Human CD3E/CD3D (P07766, 23 a.a. - 126 a.a./P04234, 22 a.a. - 105 a.a.) partial recombinant protein with a Fc tag at the C-terminus expressed in mammalian cells.
Host
Human
Form
Lyophilized
Preparation Method
Mammalian cell (Expi293) expression system
Purification
Protein A purification
Purity
> 95% (determined by SDS-PAGE)
Endotoxin Level
< 0.1 EU/ug of protein (determined by LAL method)
Activity
Immobilized human CD3E and CD3D heterodimer protein at 0.5 ug/mL (100 uL/well), dose response curve for Anti-hCD3e mAb with the EC50 of 21.69 ng/mL determined by ELISA.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Conformation
Heterodimer
Storage Buffer
Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4.
Storage Instruction
Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — CD3D
Entrez GeneID
915Protein Accession#
P07766;P04234Gene Name
CD3D
Gene Alias
CD3-DELTA, T3D
Gene Description
CD3d molecule, delta (CD3-TCR complex)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq
Other Designations
CD3D antigen, delta polypeptide|CD3d antigen, delta polypeptide (TiT3 complex)|T-cell receptor T3 delta chain|T-cell surface glycoprotein CD3 delta chain
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Gene Info — CD3E
Entrez GeneID
916Protein Accession#
P07766;P04234Gene Name
CD3E
Gene Alias
FLJ18683, T3E, TCRE
Gene Description
CD3e molecule, epsilon (CD3-TCR complex)
Omim ID
186830Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is the CD3-epsilon polypeptide, which together with CD3-gamma, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. The epsilon polypeptide plays an essential role in T-cell development. Defects in this gene cause immunodeficiency. This gene has also been linked to a susceptibility to type I diabetes in women. [provided by RefSeq
Other Designations
CD3-epsilon|CD3E antigen, epsilon polypeptide|CD3e antigen, epsilon polypeptide (TiT3 complex)|T-cell antigen receptor complex, epsilon subunit of T3|T-cell surface antigen T3/Leu-4 epsilon chain|T-cell surface glycoprotein CD3 epsilon chain
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Interactome
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Pathway
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Disease
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