CEACAM1 (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
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Specification
Product Description
Human CEACAM1 (NP_001703.2, 35 a.a. - 428 a.a.) partial recombinant protein with a 6×His tag at the C-terminus expressed in HEK293 cells.
Host
Human
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Ni-sepharose purification
Purity
> 97% (determined by SDS-PAGE)
Activity
Measured by the binding ability in a functional ELISA. Immobilized recombinant human CEACAM1 at 5 ug/mL (100 uL/well) can bind recombinant human CEACAM8 with a linear range of 0.5-3 ug/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Storage Instruction
Store at -80°C on dry atmosphere, lyophilized antibodies are stable at least 2 years.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
SDS-PAGE
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Gene Info — CEACAM1
Entrez GeneID
634Protein Accession#
P13688-1Gene Name
CEACAM1
Gene Alias
BGP, BGP1, BGPI
Gene Description
carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
Omim ID
109770Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily. Two subgroups of the CEA family, the CEA cell adhesion molecules and the pregnancy-specific glycoproteins, are located within a 1.2 Mb cluster on the long arm of chromosome 19. Eleven pseudogenes of the CEA cell adhesion molecule subgroup are also found in the cluster. The encoded protein was originally described in bile ducts of liver as biliary glycoprotein. Subsequently, it was found to be a cell-cell adhesion molecule detected on leukocytes, epithelia, and endothelia. The encoded protein mediates cell adhesion via homophilic as well as heterophilic binding to other proteins of the subgroup. Multiple cellular activities have been attributed to the encoded protein, including roles in the differentiation and arrangement of tissue three-dimensional structure, angiogenesis, apoptosis, tumor suppression, metastasis, and the modulation of innate and adaptive immune responses. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature of only two has been determined. [provided by RefSeq
Other Designations
CD66a antigen|antigen CD66|biliary glycoprotein adhesion molecule|carcinoembryonic antigen-related cell adhesion molecule 1
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Interactome
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Disease
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