PDCD1 (Human) Recombinant Protein
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Specification
Product Description
Human PDCD1 (Q8IX89, 25 a.a. - 167 a.a.) partial recombinant protein with Fc tag at C-terminal expressed in HEK293 cells.
Host
Human
Form
Lyophlized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Protein A purification
Purity
> 95% by SDS-PAGE.
Endotoxin Level
< 0.1 EU/ug of the protein by LAL method.
Activity
Immobilized PDCD1 (Human) Recombinant Protein (Cat # P6734) at 0.5 ug/mL (100 uL/well), dose response curve for Anti-PD1 Ab with the ECsub>50 of 160 ng/mL determined by ELISA.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
This protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 65-72 kDa.
Recommend Usage
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 0.22 um filtered solution of PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution with a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — PDCD1
Entrez GeneID
5133Protein Accession#
Q8IX89Gene Name
PDCD1
Gene Alias
CD279, PD1, SLEB2, hPD-1, hPD-l
Gene Description
programmed cell death 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq
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