ACE2 (Human) Recombinant Protein
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Specification
Product Description
Human ACE2 (Q9BYF1, 18 a.a. - 740 a.a.) partial recombinant protein with C-terminal Fc tag expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
109.5
Reactivity
Human
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Affinity purification
Purity
> 95% by SDS-PAGE
Activity
Measured by the binding ability in a functional ELISA. Immobilized S1 (SARS-CoV-2) RBD Recombinant Protein at 2 ug/mL (100 uL/well) can bind ACE2 (Human) Recombinant Protein (Cat # P6644). The EC50 of ACE2 (Human) Recombinant Protein (Cat # P6644) is 4-6 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
ACE2 (Human) Recombinant Protein (Cat # P6644) with hFc tag was determined by SDS-PAGE with Coomassie Blue, showing a band at 140-150 kDa.
Recommend Usage
Immunogen
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS, pH 7.4.
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term. After reconstitution to a concentration of 0.1-0.5 mg/mL in sterile distilled water, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — ACE2
Entrez GeneID
59272Protein Accession#
Q9BYF1Gene Name
ACE2
Gene Alias
ACEH, DKFZp434A014
Gene Description
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Omim ID
300335Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq
Other Designations
ACE-related carboxypeptidase|OTTHUMP00000022963|angiotensin I converting enzyme 2|angiotensin converting enzyme-like protein
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