ACE2 (Human) Recombinant Protein
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Specification
Product Description
Human ACE2 (Q9BYF1, 18 a.a. - 740 a.a.) partial recombinant protein with His-Avi tag at C-terminal expressed in HEK293 cells.
Host
Human
Theoretical MW (kDa)
86.2
Form
Lypholized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
Affinity purification
Purity
> 95% by SDS-PAGE.
Endotoxin Level
< 1.0 EU/ug of the protein by LAL method.
Activity
Measured by the binding ability in a functional ELISA. Immobilized ACE2 (Human) Recombinant Protein at 2 ug/mL (100 uL/well) can bind recombinant 2019-nCoV Spike S1 with a linear range of 0.49-27.17 ng/mL.
Quality Control Testing
SDS-PAGE Stained with Coomassie Blue
This protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 95-110 kDa.
Storage Buffer
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water._x005F_x005F_x005F_x000D__x005F_x000D__x000D_
Storage Instruction
Store the lyophilized protein at -20°C to -80°C for long term.
After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.or This product is stable at ? -70°C for up to 6 months from the date of receipt.
For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature.
Aliquot to avoid repeated freezing and thawing._x005F_x005F_x005F_x000D__x005F_x000D__x000D_Note
Result of bioactivity analysis
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Applications
SDS-PAGE
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Gene Info — ACE2
Entrez GeneID
59272Protein Accession#
Q9BYF1Gene Name
ACE2
Gene Alias
ACEH, DKFZp434A014
Gene Description
angiotensin I converting enzyme (peptidyl-dipeptidase A) 2
Omim ID
300335Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq
Other Designations
ACE-related carboxypeptidase|OTTHUMP00000022963|angiotensin I converting enzyme 2|angiotensin converting enzyme-like protein
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Interactome
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Pathway
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Disease
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Publication Reference
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Tracking B Cell Memory to SARS-CoV-2 Using Rare Cell Analysis System.
Dong-Yan Tsai, Chun-Hung Wang, Perry G Schiro, Nathan Chen, Ju-Yu Tseng.
Vaccines (Basel) 2023 Mar; 11(4):735.
Application:ELISA, Human, Human plasma.
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Tracking B Cell Memory to SARS-CoV-2 Using Rare Cell Analysis System.
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