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Functional Study

Entrez GeneID

Protein Accession#

Gene Name

PRKD3

Gene Alias

EPK2, PKC-NU, PKD3, PRKCN, nPKC-NU

Gene Description

protein kinase D3

Omim ID

Gene Ontology

Gene Summary

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phopholipase C gamma and the involvement of other PKC family members. [provided by RefSeq

Other Designations

OTTHUMP00000126953|protein kinase C, nu|protein kinase EPK2|protein-serine/threonine kinase