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Last updated: 2019/8/18

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MAPK9 (Human) Recombinant Protein BioActive

  • Catalog # : P6508
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  • Specification
  • Product Description:
  • Human MAPK9 (NP_002743.3, 1 a.a. - 364 a.a.) partial recombinant protein with GST-tag at N-terminal using E.coli expression system and activated with His-tag MAP2K4 and MAP2K7.
  • Host:
  • Viruses
  • Form:
  • Liquid
  • Preparation Method:
  • E.coli expression system.
  • Purification:
  • Glutathione sepharose chromatography.
  • Purity:
  • 0.97
  • Activity:
  • The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorecence-labeled substrate and Mg (or Mn)/ATP. Substrate: Modified Erktide, ATP: 100 uM.
  • Quality Control Testing:
  • The purity was assessed by SDS-PAGE/CBB staining.
  • Storage Buffer:
  • 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
  • Storage Instruction:
  • Stored at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 5601
  • Gene Name:
  • MAPK9
  • Gene Alias:
  • JNK-55,JNK2,JNK2A,JNK2ALPHA,JNK2B,JNK2BETA,PRKM9,SAPK,p54a,p54aSAPK
  • Gene Description:
  • mitogen-activated protein kinase 9
  • Gene Summary:
  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
  • Other Designations:
  • Jun kinase,MAP kinase 9,c-Jun N-terminal kinase 2,c-Jun kinase 2,mitogen-activated protein kinase 9 isoform JNK2 alpha2,stress-activated protein kinase JNK2
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