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Last updated: 2019/8/18

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ACVRL1 (Human) Recombinant Protein BioActive

  • Catalog # : P6459
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  • Specification
  • Product Description:
  • Human ACVRL1 (NP_000011.2, 139 a.a. - 503 a.a.) partial recombinant protein with GST-tag at N-terminal using baculovirus expression system.
  • Host:
  • Viruses
  • Form:
  • Liquid
  • Preparation Method:
  • Baculovirus expression system.
  • Purification:
  • Glutathione sepharose chromatography.
  • Purity:
  • 0.65
  • Activity:
  • The activity was determined by TR-FRET assay.The enzyme was incubated with ULight-labeled peptide and Mn/ATP. Phosphorylation was detected by Eu-labeled anti-phospho antibody. Substrate: Topo?a peptide, ATP: 100 uM.
  • Quality Control Testing:
  • The purity was assessed by SDS-PAGE/CBB staining.
  • Storage Buffer:
  • 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
  • Storage Instruction:
  • Stored at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis

  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 94
  • Gene Name:
  • ACVRL1
  • Gene Alias:
  • ACVRLK1,ALK-1,ALK1,HHT,HHT2,ORW2,SKR3,TSR-I
  • Gene Description:
  • activin A receptor type II-like 1
  • Gene Summary:
  • This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq
  • Other Designations:
  • TGF-B superfamily receptor type I,activin A receptor, type II-like kinase 1,serine/threonine-protein kinase receptor R3
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