TNFSF12 (Human) Recombinant Protein
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Specification
Product Description
Human TNFSF12 (O43508) recombinant protein expressed in E. Coli.
Sequence
MKGRKTRARRAIAAHYEVHPRPGQDGAQAGVDGTVSGWEEARINSSSPLRYNRQIGEFIVTRAGLYYLYCQVHFDEGKAVYLKLDLLVDGVLALRCLEEFSATAASSLGPQLRLCQVSGLLALRPGSSLRIRTLPWAHLKAAPFLTYFGLFQVH
Host
Escherichia coli
Theoretical MW (kDa)
17
Form
Lyophilized
Purity
> 95%
Endotoxin Level
<= 1 EUs/ug (LAL gel clot method)
Activity
The ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC is less than 10 ng/mL.
Storage Buffer
Lyophilized from PBS, pH 7.2.
Storage Instruction
Stored at -20°C to-80°C.
After reconstitution with sterile water not less than 0.1 mg/mL, store at -20°C to -80°C for 6 months, store at 4°C for 1 month.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Functional Study
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Gene Info — TNFSF12
Entrez GeneID
8742Protein Accession#
O43508Gene Name
TNFSF12
Gene Alias
APO3L, DR3LG, MGC129581, MGC20669, TWEAK
Gene Description
tumor necrosis factor (ligand) superfamily, member 12
Omim ID
602695Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Some transcripts that skip the last exon of this gene and continue with the second exon of the neighboring TNFSF13 gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq
Other Designations
APO3/DR3 ligand|TNF-related WEAK inducer of apoptosis
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