TNFSF10 (Human) Recombinant Protein
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Specification
Product Description
Human TNFSF10 (P50591) recombinant protein expressed in E. Coli.
Sequence
MRERGPQRVAAHITGTRGRSNTLSSPNSKNEKALGRKINSWESSRSGHSFLSNLHLRNGELVIHEKGFYYIYSQTYFRFQEEIKENTKNDKQMVQYIYKYTSYPDPILLMKSARNSCWSKDAEYGLYSIYQGGIFELKENDRIFVSVTNEHLIDMDHEASFFGAFLVG
Host
Escherichia coli
Theoretical MW (kDa)
18
Form
Lyophilized
Purity
> 95%
Endotoxin Level
<= 1 EUs/ug (LAL gel clot method)
Activity
The expected ED50 for this effect is 1-3 ng/mL.
Storage Buffer
Lyophilized from PBS, pH 7.2.
Storage Instruction
Stored at -20°C to-80°C.
After reconstitution with sterile water not less than 0.1 mg/mL, store at -20°C to -80°C for 6 months, store at 4°C for 1 month.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Functional Study
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Gene Info — TNFSF10
Entrez GeneID
8743Protein Accession#
P50591Gene Name
TNFSF10
Gene Alias
APO2L, Apo-2L, CD253, TL2, TRAIL
Gene Description
tumor necrosis factor (ligand) superfamily, member 10
Omim ID
603598Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
Other Designations
Apo-2 ligand|TNF-related apoptosis inducing ligand TRAIL|tumor necrosis factor (ligand) family, member 10|tumor necrosis factor apoptosis-inducing ligand splice variant delta
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Disease
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