Determined by its ability to chemoattract CXCR3 transfected cells using a concentration of 10-100 ng/mL.
Storage Buffer:
Lyophilized from PBS, pH 7.2.
Storage Instruction:
Stored at -20°C to-80°C. After reconstitution with sterile water not less than 0.1 mg/mL, store at -20°C to -80°C for 6 months, store at 4°C for 1 month. Aliquot to avoid repeated freezing and thawing.
This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq
Other Designations:
CC chemokine ILC,IL-11 Ralpha-locus chemokine,OTTHUMP00000000533,OTTHUMP00000021297,cutaneous T-cell attracting chemokine,skinkine,small inducible cytokine A27,small inducible cytokine subfamily A (Cys-Cys), member 27