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ERBB3 (Human) Recombinant Protein

  • Catalog # : P6199
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  • Specification
  • Product Description:
  • Human ERBB3 (NP_001973.2, 1 a.a - 1342 a.a) full length recombinant protein with His-Flag tag at C-terminal expressed in HEK293 cells.
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 72.8
  • Form:
  • Liquid
  • Preparation Method:
  • Mammalian cell (HEK293) expression system
  • Purification:
  • Ni affinity column
  • Purity:
  • > 90% as determined by SEC-HPLC
  • Endotoxin Level:
  • < 1.0 EU/ug as determined by the LAL method
  • Quality Control Testing:
  • SDS-PAGE (3ug/lane) stained with Coomassie Blue

    QC Testing of P6199
  • Storage Buffer:
  • In 1x PBS, pH7.4
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Application Image
  • Gene Information
  • Entrez GeneID:
  • 2065
  • Gene Name:
  • ERBB3
  • Gene Alias:
  • ErbB-3,HER3,LCCS2,MDA-BF-1,MGC88033,c-erbB-3,c-erbB3,erbB3-S,p180-ErbB3,p45-sErbB3,p85-sErbB3
  • Gene Description:
  • v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)
  • Gene Summary:
  • This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq
  • Other Designations:
  • erbB-3,lethal congenital contracture syndrome 2,v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
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