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GREM1 (Human) Recombinant ProteinBioActive

  • Catalog # : P6017
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  • Specification
  • Product Description:
  • Human GREM1 (O60565) partial recombinant protein expressed in CHO cells.
  • Sequence:
  • Host:
  • Hamster
  • Theoretical MW (kDa):
  • 18.3
  • Reactivity:
  • Human
  • Form:
  • Lyophilized
  • Preparation Method:
  • Mammalian cell (CHO) expression system
  • Purity:
  • 90%
  • Endotoxin Level:
  • Endotoxin level is < 0.1 ng/ug (< 1 EU/ug).
  • Activity:
  • Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50for this effect is 0.07-0.11 ug/ml.
  • Recommend Usage:
  • Activity assay
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from solutions contain no sodiun azide nor carrier protein
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Gene Name:
  • GREM1
  • Gene Alias:
  • Gene Description:
  • gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
  • Gene Summary:
  • This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. [provided by RefSeq
  • Other Designations:
  • cysteine knot superfamily 1, BMP antagonist 1,down-regulated in Mos-transformed cells,gremlin 1-like protein,gremlin-1,increased in high glucose-2,proliferation-inducing gene 2
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