CFB (Human) Recombinant Protein
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Specification
Product Description
Human CFB full-length recombinant protein with N-terminal hexahistidine tag expressed in in HEK293EBNA1 cells.
Host
Human
Reactivity
Human
Form
Liquid
Preparation Method
Mammalian cell (HEK293EBNA1) expression system
Concentration
1.6 mg/mL
Quality Control Testing
NuPAGE Stained with Coomassie Blue
Lane1: Reduced CFB, Lane2: Non-reduced CFB
Storage Buffer
25 mM Tris 150 mM NaCl pH 7.5 (no preservative)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
SDS-PAGE
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Gene Info — CFB
Entrez GeneID
629Gene Name
CFB
Gene Alias
BF, BFD, CFAB, FB, FBI12, GBG, H2-Bf, PBF2
Gene Description
complement factor B
Gene Ontology
HyperlinkGene Summary
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2. [provided by RefSeq
Other Designations
B-factor, properdin|C3 proaccelerator|C3 proactivator|C3/C5 convertase|OTTHUMP00000029283|OTTHUMP00000174690|glycine-rich beta-glycoprotein
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