ROS1 (Human) Recombinant Protein
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Specification
Product Description
Human ROS1 (NP_002935.2, 1883 a.a. - 2347 a.a.) partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.
Host
insect
Theoretical MW (kDa)
79
Form
Liquid
Preparation Method
Baculovirus infected insect cell (Sf21) expression system
Purification
Glutathione sepharose chromatography
Purity
54 % by SDS-PAGE/CBB staining
Activity
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: IRS1. ATP: 100 uM.
Quality Control Testing
Loading 1 ug protein in SDS-PAGE
Storage Buffer
In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.05% Brij35, 1 mM DTT, 10% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — ROS1
Entrez GeneID
6098Protein Accession#
NP_002935.2Gene Name
ROS1
Gene Alias
MCF3, ROS, c-ros-1
Gene Description
c-ros oncogene 1 , receptor tyrosine kinase
Omim ID
165020Gene Ontology
HyperlinkGene Summary
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. [provided by RefSeq
Other Designations
OTTHUMP00000017814|OTTHUMP00000040389|proto-oncogene c-ros-1 protein|proto-oncogene tyrosine-protein kinase ROS|transmembrane tyrosine-specific protein kinase|v-ros UR2 sarcoma virus oncogene homolog 1|v-ros avian UR2 sarcoma virus oncogene homolog 1
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Interactome
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Disease
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