LATS2 (Human) Recombinant Protein

Catalog # P5574

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Size:5 ug
Price: USD $ 531.00
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    +1-909-992-0619
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QC Test

Result of activity analysis
Note

Result of activity analysis

Result of activity analysis

  • Specifications

    Product Description

    Human LATS2 (NP_055387.2, 553 a.a. - 1088 a.a.) partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins

    Host

    insect

    Theoretical MW (kDa)

    89

    Form

    Liquid

    Preparation Method

    Baculovirus infected insect cell (Sf21) expression system

    Purification

    Glutathione sepharose chromatography

    Purity

    73 % by SDS-PAGE/CBB staining

    Activity

    The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: SGKtide. ATP: 1000 uM

    Quality Control Testing

    Loading 1 ug protein in SDS-PAGE

    Storage Buffer

    In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)

    Storage Instruction

    Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    Result of activity analysis

  • Applications

    Functional Study

    SDS-PAGE

  • Gene Info — LATS2

    Entrez GeneID

    26524

    Protein Accession#

    NP_055387.2

    Gene Name

    LATS2

    Gene Alias

    FLJ13161, KPM

    Gene Description

    LATS, large tumor suppressor, homolog 2 (Drosophila)

    Omim ID

    604861

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq

    Other Designations

    LATS (large tumor suppressor, Drosophila) homolog 2|LATS, large tumor suppressor, homolog 2|OTTHUMP00000018106|kinase phosphorylated during mitosis protein|serine/threonine kinase KPM|warts-like kinase

  • Interactomes
  • Diseases
  • Publication Reference
    • Epinephrine inhibits PI3Kα via the Hippo kinases.

      Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A Kesicki, Edward R Kastenhuber, Thorsten Wiederhold, Tomer M Yaron, Emily M Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N Paddock, Guoan Zhang, Benjamin D Hopkins, Owen McGuinness, Robert E Schwartz, Baran A Ersoy, Lewis C Cantley, Jared L Johnson, Marcus D Goncalves.

      Cell Reports 2023 Dec; 42(12):113535.

      Application:N/A, N/A, N/A.

Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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