LATS2 (Human) Recombinant Protein
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More Files
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Result of activity analysis
Result of activity analysis
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Specifications
Product Description
Human LATS2 (NP_055387.2, 553 a.a. - 1088 a.a.) partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells.
Host
insect
Theoretical MW (kDa)
89
Form
Liquid
Preparation Method
Baculovirus infected insect cell (Sf21) expression system
Purification
Glutathione sepharose chromatography
Purity
73 % by SDS-PAGE/CBB staining
Activity
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: SGKtide. ATP: 1000 uM
Quality Control Testing
Loading 1 ug protein in SDS-PAGE
Storage Buffer
In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — LATS2
Entrez GeneID
26524Protein Accession#
NP_055387.2Gene Name
LATS2
Gene Alias
FLJ13161, KPM
Gene Description
LATS, large tumor suppressor, homolog 2 (Drosophila)
Omim ID
604861Gene Ontology
HyperlinkGene Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq
Other Designations
LATS (large tumor suppressor, Drosophila) homolog 2|LATS, large tumor suppressor, homolog 2|OTTHUMP00000018106|kinase phosphorylated during mitosis protein|serine/threonine kinase KPM|warts-like kinase
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Interactomes
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Diseases
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Publication Reference
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Epinephrine inhibits PI3Kα via the Hippo kinases.
Ting-Yu Lin, Shakti Ramsamooj, Tiffany Perrier, Katarina Liberatore, Louise Lantier, Neil Vasan, Kannan Karukurichi, Seo-Kyoung Hwang, Edward A Kesicki, Edward R Kastenhuber, Thorsten Wiederhold, Tomer M Yaron, Emily M Huntsman, Mengmeng Zhu, Yilun Ma, Marcia N Paddock, Guoan Zhang, Benjamin D Hopkins, Owen McGuinness, Robert E Schwartz, Baran A Ersoy, Lewis C Cantley, Jared L Johnson, Marcus D Goncalves.
Cell Reports 2023 Dec; 42(12):113535.
Application：N/A, N/A, N/A.
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Epinephrine inhibits PI3Kα via the Hippo kinases.
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