GRK4 (Human) Recombinant Protein
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Specification
Product Description
Human GRK4 (NP_892027.2, 1 a.a. - 578 a.a.) full-length recombinant protein expressed in baculovirus infected Sf21 cells.
Host
insect
Theoretical MW (kDa)
67
Form
Liquid
Preparation Method
Baculovirus infected insect cell (Sf21) expression system
Purification
Glutathione sepharose chromatography
Purity
78 % by SDS-PAGE/CBB staining
Activity
The activity was measured by off-chip mobility shift assay. The enzyme was incubated with fluorescence-labeled substrate and Mg(or Mn)/ATP. The phosphorylated and unphosphorylated substrates were separated and detected by LabChip 3000. Substrate: Modified PLKtide. ATP: 100 uM.
Quality Control Testing
Loading 1 ug protein in SDS-PAGE
Storage Buffer
In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — GRK4
Entrez GeneID
2868Protein Accession#
NP_892027.2Gene Name
GRK4
Gene Alias
GPRK2L, GPRK4, GRK4a, IT11
Gene Description
G protein-coupled receptor kinase 4
Omim ID
137026Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. [provided by RefSeq
Other Designations
G protein-coupled receptor kinase 2-like|G-protein coupled receptor kinase 4
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