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Last updated: 2016/10/23

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TNFSF10 (Human) Recombinant ProteinBioActive

  • Catalog # : P5387
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  • Specification
  • Product Description:
  • Human TNFSF10 extracellular domain (91 a.a. - 281 a.a.) partial recombinant protein expressed in Escherichia coli and purified to homogeneity as a homotrimer.
  • Sequence:
    The first M is partially removed.
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 22.1 (monomer)
  • Form:
  • Liquid
  • Preparation Method:
  • Escherichia coli expression system
  • Concentration:
  • 1 mg/ml
  • Endotoxin Level:
  • < 0.1 EU/ug as determined by Endo-Safe LAL Assay.
  • Activity:
  • The biological activity of TNFSF10 is measured by its ability to induce cell death to A172 human glioblastoma cell line.
  • Quality Control Testing:
  • Loading 5 ug protein in SDS-PAGE

    QC Testing of P5387
  • Storage Buffer:
  • In 25 mM HEPES, pH7.5, 150 mM NaCl, 5 mM DTT.
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis
  • TNFSF10 induce cell death to A172 human glioblastoma cell line.

  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 8743
  • Gene Name:
  • TNFSF10
  • Gene Alias:
  • APO2L,Apo-2L,CD253,TL2,TRAIL
  • Gene Description:
  • tumor necrosis factor (ligand) superfamily, member 10
  • Gene Summary:
  • The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq
  • Other Designations:
  • Apo-2 ligand,TNF-related apoptosis inducing ligand TRAIL,tumor necrosis factor (ligand) family, member 10,tumor necrosis factor apoptosis-inducing ligand splice variant delta
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