PAK7 (Human) Recombinant Protein
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Specification
Product Description
Human PAK7 kinase domain (Q9P286, 425 a.a. - 719 a.a.) partial recombinant protein expressed in Escherichia coli.
Sequence
GPHMSRVSHEQFRAALQLVVSPGDPREYLANFIKIGEGSTGIVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHDNVVDMYSSYLVGDELWVVMEFLEGGALTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSLVGTPYWMAPEVISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAIRRIRDSLPPRVKDLHKVSSVLRGFLDLMLVREPSQRATAQELLGHPFLKLAGPPSCIVPLMRQYRHH
The first 4 residues GPHM are from Turbo3C Protease cleavage site. The underlined S is phosphorylated S602.Host
Escherichia coli
Theoretical MW (kDa)
33.9
Form
Liquid
Preparation Method
Escherichia coli expression system
Concentration
1 mg/ml
Activity
Specific activity: 4,199 pmoles/min/ug
Quality Control Testing
Loading 12 ug protein in SDS-PAGE
Storage Buffer
In 25 mM Tris-HCl pH 8.0, 150 mM NaCl, 10% glycerol, 5 mM DTT.
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — PAK7
Entrez GeneID
57144Protein Accession#
Q9P286Gene Name
PAK7
Gene Alias
KIAA1264, MGC26232, PAK5
Gene Description
p21 protein (Cdc42/Rac)-activated kinase 7
Omim ID
608038Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
OTTHUMP00000030258|OTTHUMP00000030259|OTTHUMP00000030260|p21(CDKN1A)-activated kinase 7|p21-activated kinase 7|protein kinase PAK5|serine/threonine-protein kinase PAK7
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Interactome
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Disease
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