Native protein purified from fresh, pooled human plasma
>= 98% by SDS-PAGE
Lyophilized from 0.01 M ammonium bicarbonate
Store at -20°C or lower on dry atmosphere. After reconstitution with aqueous buffer, store at 2-8°C no longer than 4 weeks.
Universal Precautions. Safe laboratory practices should be used when handling this material.
Apolipoprotein H, also known as beta 2-glycoprotein I (beta 2-GPI), is a glycoprotein of 48,000 daltons that is associated with all major lipoprotein fractions. It is soluble in aqueous solutions, unlike other Apo-lipoproteins.
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq