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Last updated: 2016/12/4

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PLAU (Human) Native Protein

  • Catalog # : P4957
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  • Specification
  • Product Description:
  • Human PLAU (low molecular weight) native protein from human urine.
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 33
  • Form:
  • Liquid
  • Preparation Method:
  • Native protein purified from human urine
  • Purification:
  • Column chromatography
  • Concentration:
  • 0.44 mg/mL
  • Purity:
  • > 98% by SDS-PAGE
  • Storage Buffer:
  • In 0.05 M sodium acetate, 0.1 M NaCl, pH 7.4 (1 mM EDTA)
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • SDS-PAGE
  • Application Image
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 5328
  • Gene Name:
  • PLAU
  • Gene Alias:
  • ATF,UPA,URK,UROKINASE,u-PA
  • Gene Description:
  • plasminogen activator, urokinase
  • Gene Summary:
  • This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000019849,U-plasminogen activator,antagonist of uPA,plasminogen activator, urinary,urokinase plasminogen activator,urokinase-type plasminogen activator amino-terminal fragment
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