TNFRSF4 (Human) Recombinant Protein
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Specification
Product Description
Human TNFRSF4 Recombinant protein fused to murine IgG2a Fc purifird from CHO cells.
Sequence
TNFRSF4 mature: lhcvgdtypsndrcchecrpgngmvsrcsrsqntvcrpcgpgfyndvvsskpckpctwcnlrsgserkqlctatqdtvcrcragtqpldsykpgvdcapcppghfspgdnqackpwtnctlagkhtlqpasnssdaicedrdppatqpqetqgpparpitvqpteawprtsqgpstr
Fused to murine IgG2a Fc: eprgptikpcppckcpapnllggpsvfifppkikdvlmislspivtcvvvdvseddpdvqiswfvnnvevhtaqtqthredynstlrvvsalpiqhqdwmsgkefkckvnnkdlpapiertiskpkgsvrapqvyvlpppeeemtkkqvtltcmvtdfmpediyvewtnngktelnykntepvldsdgsyfmysklrvekknwvernsyscsvvheglhnhhttksfsrtpgHost
Mammals
Theoretical MW (kDa)
45.6
Form
Liquid
Preparation Method
Mammalian cell (CHO) expression system
Purification
Size purification
Concentration
0.5 mg/mL
Storage Buffer
In 50 mM sodium phosphate, 100 mM NaCl, pH 7.6. (0.5 mg/mL gentamicin sulfate)
Storage Instruction
Store at 4°C. This product is stable for at least 3 months.
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Applications
SDS-PAGE
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Gene Info — TNFRSF4
Entrez GeneID
7293Gene Name
TNFRSF4
Gene Alias
ACT35, CD134, OX40, TXGP1L
Gene Description
tumor necrosis factor receptor superfamily, member 4
Omim ID
600315Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq
Other Designations
ATC35 antigen|CD134 antigen|OTTHUMP00000001522|OX40 antigen|OX40 cell surface antigen|OX40 homologue|lymphoid activation antigene ACT35|tax-transcriptionally activated glycoprotein 1 receptor
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