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ELA2 (Human) Native ProteinBioActive

  • Catalog # : P4923
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  • Specification
  • Product Description:
  • Human ELA2 (30 a.a. - 247 a.a.) partial native protein from human blood.
  • Host:
  • Human
  • Theoretical MW (kDa):
  • 29
  • Form:
  • Liquid
  • Preparation Method:
  • Native protein purified from human blood
  • Purification:
  • Saltprecipitation/Ion Exchange Chromatography/Gelfiltration
  • Concentration:
  • 0.2 mg/mL
  • Purity:
  • > 95% by SDS-PAGE
  • Activity:
  • ≥ 18 mU/mg
  • Quality Control Testing:
  • 15% SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4923
  • Storage Buffer:
  • In 10 mM acetate, pH 5.5
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 1991
  • Gene Name:
  • ELA2
  • Gene Alias:
  • GE,HLE,HNE,NE,PMN-E
  • Gene Description:
  • elastase 2, neutrophil
  • Gene Summary:
  • Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq
  • Other Designations:
  • bone marrow serine protease,granulocyte-derived elastase,leukocyte elastase,medullasin,polymorphonuclear elastase
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