NTRK3 (Human) Recombinant Protein
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Specification
Product Description
Human NTRK3 (NM_002530.2, 510 a.a. - 825 a.a.) partial Recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
64.87
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
GST-Affinity Chromatography
Concentration
0.085 ug/uL
Activity
35 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Hepes, 100 mM NaCl, pH 7.5 (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — NTRK3
Entrez GeneID
4916Protein Accession#
NM_002530.2Gene Name
NTRK3
Gene Alias
TRKC, gp145(trkC)
Gene Description
neurotrophic tyrosine kinase, receptor, type 3
Omim ID
191316Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq
Other Designations
ETS related protein-neurotrophic receptor tyrosine kinase fusion protein|ETV6-NTRK3 fusion|NT-3 growth factor receptor|OTTHUMP00000192915|neurotrophin 3 receptor|tyrosine kinase receptor C
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Disease
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