NTRK1 (Human) Recombinant Protein
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Specification
Product Description
Human NTRK1 (NM_002529.2, 443 a.a. - 796 a.a.) partial Recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
69.726
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
GST-Affinity Chromatography
Activity
100 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM HEPES, 100 mM NaCl, pH 7.5 (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — NTRK1
Entrez GeneID
4914Protein Accession#
NM_002529.2Gene Name
NTRK1
Gene Alias
DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
Gene Description
neurotrophic tyrosine kinase, receptor, type 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Other Designations
OTTHUMP00000038736|Oncogene TRK|high affinity nerve growth factor receptor|tyrosine kinase receptor A
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