TGFBR1 (Human) Recombinant Protein
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Specification
Product Description
Human TGFBR1 (NM_004612, 200 a.a. - 503 a.a.) partial recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
64.16800000000001
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
GST affinity chromatography
Concentration
0.193 ug/uL
Activity
501 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Hepes, 100 mM NaCl, pH 7.5. (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — TGFBR1
Entrez GeneID
7046Protein Accession#
NM_004612Gene Name
TGFBR1
Gene Alias
AAT5, ACVRLK4, ALK-5, ALK5, LDS1A, LDS2A, SKR4, TGFR-1
Gene Description
transforming growth factor, beta receptor 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000021783|activin A receptor type II-like kinase, 53kD|activin A receptor type II-like kinase, 53kDa|activin receptor-like kinase 5|serine/threonine-protein kinase receptor R4|transforming growth factor beta receptor I|transforming growth factor,
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Interactome
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Pathway
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Disease
- Abnormalities
- Adenocarcinoma
- Adenoma
- Aneurysm
- Aortic Aneurysm
- Aortic Rupture
- Asthma
- Atherosclerosis
- Behcet Syndrome
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