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MUSK (Human) Recombinant ProteinBioActive

  • Catalog # : P4729
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  • Specification
  • Product Description:
  • Human MUSK (NM_005592, 529 a.a. - 869 a.a.) partial recombinant protein with GST-His tag expressed in Sf9 cells.
  • Host:
  • Insect
  • Theoretical MW (kDa):
  • 68.345
  • Form:
  • Liquid
  • Preparation Method:
  • Insect cell (Sf9) expression system
  • Purification:
  • One-step affinity purification using GSH-agarose
  • Concentration:
  • 0.159 ug/uL
  • Activity:
  • 19 pmol/ug x min
  • Quality Control Testing:
  • 2 ug/lane SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4729
  • Storage Buffer:
  • In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 20% glycerol)
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing
  • Note:
  • Result of activity analysis

  • Applications
  • Functional Study
  • Application Image
  • Functional Study
  • Gene Information
  • Entrez GeneID:
  • 4593
  • Gene Name:
  • MUSK
  • Gene Alias:
  • MGC126323,MGC126324
  • Gene Description:
  • muscle, skeletal, receptor tyrosine kinase
  • Gene Summary:
  • Intercellular communication is often mediated by receptors on the surface of one cell that recognize and are activated by specific protein ligands released by other cells. Members of one class of cell surface receptors, receptor tyrosine kinases (RTKs), are characterized by having a cytoplasmic domain containing intrinsic tyrosine kinase activity. This kinase activity is regulated by the binding of a cognate ligand to the extracellular portion of the receptor. DeChiara et al. (1996) [PubMed 8653786] noted that the RTKs, known to be expressed in cell type-specific fashions, play a role critical for the growth and differentiation of those cell types. For example, members of the neural-specific TRK family that recognize nerve growth factor are absolutely required for the survival and development of discrete neuronal subpopulations, and the receptor tyrosine kinases TIE1 (MIM 600222) and TIE2 (MIM 600221) play a critical role in the development of normal blood vessels.[supplied by OMIM
  • Other Designations:
  • protein-tyrosine kinase,receptor tyrosine kinase,skeletal muscle receptor tyrosine kinase
  • Related Disease
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