JAK3 (Human) Recombinant Protein
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Specification
Product Description
Human JAK3 (NP_000206.1, 781 a.a. - 1124 a.a.) partial recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
68.379
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
GST-Affinity Chromatography
Activity
5 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — JAK3
Entrez GeneID
3718Protein Accession#
NP_000206.1Gene Name
JAK3
Gene Alias
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Gene Description
Janus kinase 3 (a protein tyrosine kinase, leukocyte)
Omim ID
600173Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Janus kinase (JAK) family of tyrosine kinases involved in cytokine receptor-mediated intracellular signal transduction. It is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations in this gene are associated with autosomal SCID (severe combined immunodeficiency disease). [provided by RefSeq
Other Designations
Janus kinase 3|leukocyte Janus kinase|tyrosine-protein kinase JAK3
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Interactome
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Pathway
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Disease
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Publication Reference
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Design and Synthesis of a Highly Selective JAK3 Inhibitor for the Treatment of Rheumatoid Arthritis.
He L, Pei H, Lan T, Tang M, Zhang C, Chen L.
Archiv Der Pharmazie 2017 Sep; 350(11).
Application:Func, Recombinant protein.
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Design and Synthesis of a Highly Selective JAK3 Inhibitor for the Treatment of Rheumatoid Arthritis.
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