IGF1R (Human) Recombinant Protein
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Specification
Product Description
Human IGF1R (NM_000875, 954- 1367 a.a.) partial recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
76.532
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
One-step affinity purification using_x005F_x000D__x000D_ GSH-agarose
Concentration
0.183 ug/uL
Activity
250 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IGF1R
Entrez GeneID
3480Protein Accession#
NM_000875Gene Name
IGF1R
Gene Alias
CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Gene Description
insulin-like growth factor 1 receptor
Omim ID
147370Gene Ontology
HyperlinkGene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. [provided by RefSeq
Other Designations
soluble IGF1R variant 1|soluble IGF1R variant 2
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Interactome
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Pathway
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Disease
- Abortion
- Adenocarcinoma
- Adenoma
- Alzheimer disease
- Anemia
- Aneuploidy
- Atherosclerosis
- Bacteremia
- Barrett Esophagus
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