HCK (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
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Specification
Product Description
Human HCK (NM_002110, 1 a.a. - 505 a.a.) full-length recombinant protein with GST-His tag expressed in Sf9 cells.
Host
insect
Theoretical MW (kDa)
86.70699999999979
Form
Liquid
Preparation Method
Insect cell (Sf9) expression system
Purification
One-step affinity purification using GSH-agarose
Concentration
0.143 ug/uL
Activity
34 pmol/ug x min
Quality Control Testing
2 ug/lane SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawingNote
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — HCK
Entrez GeneID
3055Protein Accession#
NM_002110Gene Name
HCK
Gene Alias
JTK9
Gene Description
hemopoietic cell kinase
Omim ID
142370Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a protein-tyrosine kinase that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms, that have different subcellular localization. [provided by RefSeq
Other Designations
tyrosine protein kinase HCK
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Interactome
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Pathway
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Disease
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Publication Reference
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Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.
Kamaldeep Dhami, Anirban Chakraborty, Tarikere L. Gururaja, Leo W.-K. Cheung, Chaohong Sun, Felix DeAnda and XiaoDong Huang.
Science Signaling 2022 May; 15(736):eabg5216.
Application：Func, Peptides.
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Kinase-deficient BTK mutants confer ibrutinib resistance through activation of the kinase HCK.
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