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Functional Study

SDS-PAGE

Entrez GeneID

Protein Accession#

Gene Name

CCNC

Gene Alias

CycC

Gene Description

cyclin C

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000016897

Entrez GeneID

Protein Accession#

Gene Name

CDK8

Gene Alias

K35, MGC126074, MGC126075

Gene Description

cyclin-dependent kinase 8

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit cyclin C are components of the RNA polymerase II holoenzyme complex, which phosphorylates the carboxy-terminal domain (CTD) of the largest subunit of RNA polymerase II. This kinase has also been shown to regulate transcription by targeting the CDK7/cyclin H subunits of the general transcription initiation factor IIH (TFIIH), thus providing a link between the 'Mediator-like' protein complexes and the basal transcription machinery. [provided by RefSeq

Other Designations

CDK8 protein kinase|OTTHUMP00000018158|cell division protein kinase 8|protein kinase K35