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CDK7/CCNH/MNAT1 (Human) Recombinant ProteinBioActive

  • Catalog # : P4662
  • Visit Frequency :
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  • Specification
  • Product Description:
  • Human CDK7 (NM_001799, 1 a.a. - 346a.a.) and CCNH (NM_001239, 1 a.a. - 323 a.a.) and MNAT1 (NM_002431, 1 a.a. - 309 a.a.) recombinant protein with GST-His tag expressed in Sf9 cells.
  • Host:
  • Insect
  • Theoretical MW (kDa):
  • CDK7: 68.934 , CCNH:
  • Form:
  • Liquid
  • Preparation Method:
  • Insect cell (Sf9) expression system
  • Purification:
  • One-step affinity purification using GSH-agarose
  • Concentration:
  • 0.139 ug/uL
  • Activity:
  • 22 pmol/ug x min
  • Quality Control Testing:
  • 2 ug/lane SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4662
  • Storage Buffer:
  • In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 4 mM reduced glutathione, 20% glycerol)
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing
  • Note:
  • Result of activity analysis

  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 1022
  • Protein Accession#:
  • NM_001799 (Gene ID : 1022);NM_001239 (Gene ID : 902);NM_002431 (Gene ID : 4331)
  • Gene Name:
  • CDK7
  • Gene Alias:
  • CAK1,CDKN7,MO15,STK1,p39MO15
  • Gene Description:
  • cyclin-dependent kinase 7
  • Gene Summary:
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. [provided by RefSeq
  • Other Designations:
  • 39 KDa protein kinase,Cdk-activating kinase,cell division protein kinase 7,cyclin-dependent kinase 7 (MO15 homolog, Xenopus laevis, cdk-activating kinase),homolog of Xenopus MO15 Cdk-activating kinase,kinase subunit of CAK,serine/threonine kinase stk1,ser
  • Gene Information
  • Entrez GeneID:
  • 902
  • Protein Accession#:
  • NM_001799 (Gene ID : 1022);NM_001239 (Gene ID : 902);NM_002431 (Gene ID : 4331)
  • Gene Name:
  • CCNH
  • Gene Alias:
  • CAK,p34,p37
  • Gene Description:
  • cyclin H
  • Gene Summary:
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK7 kinase and ring finger protein MAT1. The kinase complex is able to phosphorylate CDK2 and CDC2 kinases, thus functions as a CDK-activating kinase (CAK). This cyclin and its kinase partner are components of TFIIH, as well as RNA polymerase II protein complexes. They participate in two different transcriptional regulation processes, suggesting an important link between basal transcription control and the cell cycle machinery. [provided by RefSeq
  • Other Designations:
  • CDK-activating kinase,MO15-associated protein,cyclin-dependent kinase-activating kinase
  • Gene Information
  • Entrez GeneID:
  • 4331
  • Protein Accession#:
  • NM_001799 (Gene ID : 1022);NM_001239 (Gene ID : 902);NM_002431 (Gene ID : 4331)
  • Gene Name:
  • MNAT1
  • Gene Alias:
  • MAT1,RNF66,TFB3
  • Gene Description:
  • menage a trois homolog 1, cyclin H assembly factor (Xenopus laevis)
  • Gene Summary:
  • Cyclin-dependent kinases (CDKs), which play an essential role in cell cycle control of eukaryotic cells, are phosphorylated and thus activated by the CDK-activating kinase (CAK). CAK is a multisubunit protein that includes CDK7 (MIM 601955), cyclin H (CCNH; MIM 601953), and MAT1. MAT1 (for 'menage a trois-1') is involved in the assembly of the CAK complex.[supplied by OMIM
  • Other Designations:
  • cyclin G1 interacting protein,cyclin H assembly factor,menage a trois 1 (CAK assembly factor)
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  • Interactome
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