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CDK6/CCND1 (Human) Recombinant ProteinBioActive

  • Catalog # : P4661
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  • Specification
  • Product Description:
  • Human CDK6(NM_001259, 1 a.a. - 326 a.a.) and CCND1 (NM_053056.2, 4 a.a. - 295 a.a.) recombinanat protein with GST tag expressed in Sf9 cells.
  • Host:
  • Insect
  • Theoretical MW (kDa):
  • CDK6: 63.279 , CCND1
  • Form:
  • Liquid
  • Preparation Method:
  • Insect cell (Sf9) expression system
  • Purification:
  • One-step affinity purification using GSH-agarose
  • Concentration:
  • 0.725 ug/uL
  • Activity:
  • 14 pmol/ug x min
  • Quality Control Testing:
  • 2 ug/lane SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4661
  • Storage Buffer:
  • In 50 mM Tris-HCl, 100 mM NaCl, pH 8.0. (5 mM DTT, 15 mM reduced glutathione, 20% glycerol)
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing
  • Note:
  • Result of activity analysis

  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 1021
  • Protein Accession#:
  • NM_001259 (Gene ID : 1021);NM_053056.2 (Gene ID : 595)
  • Gene Name:
  • CDK6
  • Gene Alias:
  • MGC59692,PLSTIRE,STQTL11
  • Gene Description:
  • cyclin-dependent kinase 6
  • Gene Summary:
  • The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. [provided by RefSeq
  • Other Designations:
  • cell division protein kinase 6
  • Gene Information
  • Entrez GeneID:
  • 595
  • Protein Accession#:
  • NM_001259 (Gene ID : 1021);NM_053056.2 (Gene ID : 595)
  • Gene Name:
  • CCND1
  • Gene Alias:
  • BCL1,D11S287E,PRAD1,U21B31
  • Gene Description:
  • cyclin D1
  • Gene Summary:
  • The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. [provided by RefSeq
  • Other Designations:
  • B-cell CLL/lymphoma 1,G1/S-specific cyclin D1
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