Products

Functional Study

SDS-PAGE

Entrez GeneID

Protein Accession#

Gene Name

CCNA2

Gene Alias

CCN1, CCNA

Gene Description

cyclin A2

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. In contrast to cyclin A1, which is present only in germ cells, this cyclin is expressed in all tissues tested. This cyclin binds and activates CDC2 or CDK2 kinases, and thus promotes both cell cycle G1/S and G2/M transitions. [provided by RefSeq

Other Designations

cyclin A

Entrez GeneID

Protein Accession#

Gene Name

CDK2

Gene Alias

p33(CDK2)

Gene Description

cyclin-dependent kinase 2

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein kinase is highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2. It is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. This protein associates with and regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene have been reported. [provided by RefSeq

Other Designations

cdc2-related protein kinase|cell devision kinase 2|p33 protein kinase