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Functional Study

SDS-PAGE

Entrez GeneID

Protein Accession#

Gene Name

CCNB1

Gene Alias

CCNB

Gene Description

cyclin B1

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34(cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript, that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. [provided by RefSeq

Other Designations

G2/mitotic-specific cyclin B1

Entrez GeneID

Protein Accession#

Gene Name

CDC2

Gene Alias

CDC28A, CDK1, DKFZp686L20222, MGC111195

Gene Description

cell division cycle 2, G1 to S and G2 to M

Omim ID

Gene Ontology

Gene Summary

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000019660|cell cycle controller CDC2|cell division control protein 2 homolog|cell division cycle 2 protein|cyclin-dependent kinase 1|p34 protein kinase