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Last updated: 2016/11/27

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IL17A (Human) Recombinant ProteinBioActive

  • Catalog # : P4579
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  • Specification
  • Product Description:
  • Human IL17A (Q16552) recombinant protein expressed in Escherichia coli.
  • Sequence:
  • MIVKAGITIPRNPGCPNSEDKNFPRTVMVNLNIHNRNTNTNPKRSSDYYNRSTSPWNLHRNEDPERYPSVIWEAKCRHLGCINADGNVDYHMNSVPIQQEILVLRREPPHCPNSFRLEKILVSVGCTCVTPIVHHVA
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 31
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Endotoxin Level:
  • < 0.1 EU/ug
  • Activity:
  • The activity is determined by the dose-dependent production of IL-6 by mouse NIH 3T3 fibroblasts and is typically 1.5-7 ng/mL.
  • Quality Control Testing:
  • 1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue

    QC Testing of P4579
    Lane 1: non-reducing conditions
    Lane 2: reducing conditions
  • Storage Buffer:
  • No additive
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with sterilized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis
  • Serial dilutions of human IL17A (starting at 800 ng/mL) were added to NIH 3T3 cells. After 48 hours, production of mouse IL-6 was measured and the linear portion of the curve was us used to calculate the ED50.


  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 3605
  • Gene Name:
  • IL17A
  • Gene Alias:
  • CTLA8,IL-17,IL-17A,IL17
  • Gene Description:
  • interleukin 17A
  • Gene Summary:
  • The protein encoded by this gene is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000016597,cytotoxic T-lymphocyte-associated antigen 8,cytotoxic T-lymphocyte-associated protein 8,cytotoxic T-lymphocyte-associated serine esterase 8,interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8)
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