TGFB1 (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
Serial dilutions of Human TGFB1 (starting at 10 ng/mL) were added to HT-2 cultured with IL-4. Cell proliferation was measured and the linear portion of the curve was us used to calculate the ED50.
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Specification
Product Description
Human TGFB1 (P01137) recombinant protein expressed in HEK293 cells.
Sequence
ALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS
Host
Human
Theoretical MW (kDa)
25
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the dose-dependent inhibition of IL-4-induced proliferation of mouse HT-2 cells. The expected ED50 for this effect is 0.1-0.15 ng/mL.
Storage Buffer
Lyophilized with 10 mM HCl, 50 ug BSA per mg/mL of protein.
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — TGFB1
Entrez GeneID
7040Protein Accession#
P01137Gene Name
TGFB1
Gene Alias
CED, DPD1, TGFB, TGFbeta
Gene Description
transforming growth factor, beta 1
Gene Ontology
HyperlinkGene Summary
TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA (MIM 190170) in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for this peptide. TGFB1, TGFB2 (MIM 190220), and TGFB3 (MIM 190230) all function through the same receptor signaling systems.[supplied by OMIM
Other Designations
TGF-beta 1 protein|diaphyseal dysplasia 1, progressive|transforming growth factor-beta 1
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Disease
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