Product Browser

Last updated: 2016/12/4

Product Compare

Product Compare Cancel Click this icon to add products to compare list. Select up to 10 products.

Quick Order (Tutorial)

Input Catalog #,
place order here!
Catalog # :
  • Where to buy
  • Choose your location

TNFRSF1A (Human) Recombinant ProteinBioActive

  • Catalog # : P4575
  • Visit Frequency :
  • Countries :
  • Specification
  • Product Description:
  • Human TNFRSF1A recombinant protein expressed in Escherichia coli.
  • Sequence:
  • MDSVCPQGKYIHPQNNSICCTKCHKGTYLYNDCPGPGQDTDCRECESSGSFTASENHLRHCLSCSKCRKEMGQVEKSSCTVDRDTVCGCRKNQYRHYWSENLFQCFNCSLCLNGTVHLSCQEKQNTVCTCHAGFFLRENECVSCSNCKKSLECTKLCLPQIEN
  • Host:
  • Escherichia coli
  • Theoretical MW (kDa):
  • 20.9
  • Form:
  • Lyophilized
  • Preparation Method:
  • Escherichia coli expression system
  • Endotoxin Level:
  • < 0.1 EU/ug
  • Activity:
  • The activity is determined by the ability to inhibit the cytolysis 1 ng/mL TNF? has on mouse L929 cells in the presence of Actinomycin D. The expected ED50 for this effect is 8-12 ng/mL.
  • Quality Control Testing:
  • 1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue

    QC Testing of P4575
    Lane 1: non-reducing conditions
    Lane 2: reducing conditions
  • Storage Buffer:
  • Lyophilized with 10 mM Na2PO4, pH 7.5.
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with sterilized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • Result of activity analysis
  • 929 cells were cultured with 1 ng/mL human TNF and 1 ug/mL Actinomycin D, plus serial dilutions of human TNFRSF1A from 0-10 ug/mL. Cell proliferation was measured after 24 hours and the linear portion of the curve was us used to calculate the ED50.


  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 7132
  • Gene Name:
  • TNFRSF1A
  • Gene Alias:
  • CD120a,FPF,MGC19588,TBP1,TNF-R,TNF-R-I,TNF-R55,TNFAR,TNFR1,TNFR55,TNFR60,p55,p55-R,p60
  • Gene Description:
  • tumor necrosis factor receptor superfamily, member 1A
  • Gene Summary:
  • The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. [provided by RefSeq
  • Other Designations:
  • tumor necrosis factor binding protein 1,tumor necrosis factor receptor 1,tumor necrosis factor receptor type 1,tumor necrosis factor-alpha receptor
  • Related Disease
  • RSS
  • YouTube
  • Linkedin
  • Facebook