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FGFR3 (Human) Recombinant Protein

  • Catalog # : P4557
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  • Specification
  • Product Description:
  • Human FGFR3 (NP_000133.1, 1 a.a. - 372 a.a.) partial recombinant protein with Fc-His tag expressed in HEK293E cells.
  • Theoretical MW (kDa):
  • 66.4407
  • Form:
  • Liquid
  • Preparation Method:
  • Mammalian cell HEK293E expression system
  • Purity:
  • > 90% by SDS-PAGE
  • Quality Control Testing:
  • 10% SDS-PAGE Stained with Coomassie Blue

    QC Testing of P4557
  • Storage Buffer:
  • In PBS, pH 7.4.
  • Storage Instruction:
  • Store at -80°C.
    Aliquot to avoid repeated freezing and thawing
  • Applications
  • Functional Study
  • SDS-PAGE
  • Application Image
  • Functional Study
  • SDS-PAGE
  • Gene Information
  • Entrez GeneID:
  • 2261
  • Gene Name:
  • FGFR3
  • Gene Alias:
  • ACH,CD333,CEK2,HSFGFR3EX,JTK4
  • Gene Description:
  • fibroblast growth factor receptor 3
  • Gene Summary:
  • This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000149959,achondroplasia, thanatophoric dwarfism,hydroxyaryl-protein kinase,tyrosine kinase JTK4
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