FGFR3 (Human) Recombinant Protein
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Specification
Product Description
Human FGFR3 (NP_000133.1, 1 a.a. - 372 a.a.) partial recombinant protein with Fc-His tag expressed in HEK293E cells.
Theoretical MW (kDa)
66.4407
Form
Liquid
Preparation Method
Mammalian cell HEK293E expression system
Purity
> 90% by SDS-PAGE
Quality Control Testing
10% SDS-PAGE Stained with Coomassie Blue
Storage Buffer
In PBS, pH 7.4.
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing -
Applications
Functional Study
SDS-PAGE
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Gene Info — FGFR3
Entrez GeneID
2261Protein Accession#
NP_000133.1Gene Name
FGFR3
Gene Alias
ACH, CD333, CEK2, HSFGFR3EX, JTK4
Gene Description
fibroblast growth factor receptor 3
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq
Other Designations
OTTHUMP00000149959|achondroplasia, thanatophoric dwarfism|hydroxyaryl-protein kinase|tyrosine kinase JTK4
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