IL19 (Human) Recombinant Protein
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Specification
Product Description
Human IL19 (Q9UHD0) recombinant protein expressed in Escherichia coli.
Sequence
MLRRCLISTDMHHIEESFQEIKRAIQAKDTFPNVTILSTLETLQIIKPLDVCCVTKNLLAFYVDRVFKDHQEPNPKILRKISSIANSFLYMQKTLRQCQEQRQCHCRQEATNATRVIHDNYDQLEVHAAAIKSLGELDVFLAWINKNHEVMFSA
Host
Escherichia coli
Theoretical MW (kDa)
17.9
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the activation of STAT following receptor-ligand interaction.
Quality Control Testing
1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue
Non-reducing conditions
Storage Buffer
Lyophilized from 10 mM sodium citrate, pH 5.0
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Functional Study
SDS-PAGE
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Gene Info — IL19
Entrez GeneID
29949Protein Accession#
Q9UHD0Gene Name
IL19
Gene Alias
IL-10C, MDA1, NG.1, ZMDA1
Gene Description
interleukin 19
Omim ID
605687Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq
Other Designations
melanoma differentiation associated protein-like protein
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Pathway
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Disease
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