IL11 (Human) Recombinant Protein
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Lane 1: non-reducing conditions
Lane 2: reducing conditions
Result of activity analysis
Result of activity analysis
Serial dilutions of human IL11 (starting at 100 ng/mL) were added to T-11 cells growing the presence of 2 ng/mL IL-6. After 91 hours, cell proliferation was measured and the linear portion of the curve was us used to calculate the ED50.
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Specification
Product Description
Human IL11 (P20809) recombinant protein expressed in Escherichia coli.
Sequence
MPGPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL
Host
Escherichia coli
Theoretical MW (kDa)
19.3
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the dose-dependent proliferation of TF-1 cells. The expected ED50 for this effect is 10 ng/mL; 1.0 x 10^5 units/mg.
Quality Control Testing
1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue
Lane 1: non-reducing conditions
Lane 2: reducing conditionsStorage Buffer
Lyophilized from a sterile (0.2 micron) filtered aqueous solution (0.1% trifluoroacetic acid (TFA)).
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IL11
Entrez GeneID
3589Protein Accession#
P20809Gene Name
IL11
Gene Alias
AGIF, IL-11
Gene Description
interleukin 11
Omim ID
147681Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. [provided by RefSeq
Other Designations
adipogenesis inhibitory factor|oprelvekin
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Interactome
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Pathway
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Disease
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