IL1A (Human) Recombinant Protein
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Specifications
Product Description
Human IL1A (P01583) recombinant protein expressed in Escherichia coli.
Sequence
SAPFSFLSNVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGAYKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETNLLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQA
Host
Escherichia coli
Theoretical MW (kDa)
18
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the dose-dependent proliferation of mouse D10S cells. The expected ED50 for this effect is 0.6-0.8 pg/mL.
Quality Control Testing
1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue
Non-reducing conditions
Storage Buffer
No additive
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IL1A
Entrez GeneID
3552Protein Accession#
P01583Gene Name
IL1A
Gene Alias
IL-1A, IL1, IL1-ALPHA, IL1F1
Gene Description
interleukin 1, alpha
Omim ID
147760Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq
Other Designations
IL1A (IL1F1)|hematopoietin-1|preinterleukin 1 alpha|pro-interleukin-1-alpha
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Interactomes
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Pathways
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Diseases
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