IFNG (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
The specific activity, as determined in a viral challenge assay using EMC virus on L929 cells, is 5.8-8.64 x 107 Units/mg. The corresponding ED50 is 0.02-0.011 ng/mL.
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Specification
Product Description
Human IFNG (P01579) recombinant protein expressed in Escherichia coli.
Sequence
MQDPYVKEAENLKKYFNAGHSDVADNGTLFLGILKNWKEESDRKIMQSQIVSFYFKLFKNFKDDQSIQKSVETIKEDMNVKFFNSNKKKRDDFEKLTNYSVTDLNVQRKAIHELIQVMAELSPAAKTGKRKRSQMLFQGRRASQ
Host
Escherichia coli
Theoretical MW (kDa)
16.88
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the viral resistance assay using L929 cells is 5.8-8.8x107 Units/mg. The expected ED50 for this effect is 0.01-0.02 ng/mL.
Storage Buffer
Lyophilized from 5 mM Na2PO4, 50 mM NaCl, pH 7.2
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — IFNG
Entrez GeneID
3458Protein Accession#
P01579Gene Name
IFNG
Gene Alias
IFG, IFI
Gene Description
interferon, gamma
Gene Ontology
HyperlinkGene Summary
Interferon-gamma (IFNG), or type II interferon, is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Aberrant IFNG expression is associated with a number of autoinflammatory and autoimmune diseases. The importance of IFNG in the immune system stems in part from its ability to inhibit viral replication directly, but most importantly derives from its immunostimulatory and immunomodulatory effects. IFNG is produced predominantly by natural killer (NK) and natural killer T (NKT) cells as part of the innate immune response, and by CD4 (MIM 186940) and CD8 (see MIM 186910) cytotoxic T lymphocyte (CTL) effector T cells once antigen-specific immunity develops (Schoenborn and Wilson, 2007 [PubMed 17981204]).[supplied by OMIM
Other Designations
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Interactome
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Pathway
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Disease
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