GDF5 (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
Serial dilutions of human GDF5, starting at 5 ug/mL, were added to ATDC-5 cells growing in the presence of 4 ug/mL heparin. Alkaline phosphate activity was measure after 67 hours and the linear portion of the curve was us used to calculate the ED50.
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Specifications
Product Description
Human GDF5 (P43026) recombinant protein expressed in Escherichia coli.
Sequence
MAPLATRQGKRPSKNLKARCSRKALHVNFKDMGWDDWIIAPLEYEAFHCEGLCEFPLRSHLEPTNHAVIQTLMNSMDPESTPPTCCVPTRLSPISILFIDSANNVVYKQYEDMVVESCGCR
Host
Escherichia coli
Theoretical MW (kDa)
26.8
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the ability to induce alkaline phosphatase activity in ATDC5 cells. The expected ED50 for this effect is 8-12 ng/mL.
Storage Buffer
No additive
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — GDF5
Entrez GeneID
8200Protein Accession#
P43026Gene Name
GDF5
Gene Alias
BMP14, CDMP1, LAP4, SYNS2
Gene Description
growth differentiation factor 5
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. [provided by RefSeq
Other Designations
OTTHUMP00000030755|OTTHUMP00000061644|cartilage-derived morphogenetic protein-1
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Interactomes
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