FGF4 (Human) Recombinant Protein
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Result of activity analysis
Result of activity analysis
3T3 cells were cultured with 0 to 1 ug/mL human FGF4. Cell proliferation was measured after 42 hours and the linear portion of the curve was us used to calculate the ED50.
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Specification
Product Description
Human FGF4 (P08620) recombinant protein expressed in Escherichia coli.
Sequence
MAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL
Host
Escherichia coli
Theoretical MW (kDa)
19
Form
Lyophilized
Preparation Method
Escherichia coli expression system
Endotoxin Level
< 0.1 EU/ug
Activity
The activity is determined by the ability to induce the proliferation of mouse NR6R-3T3 fibroblasts. The expected ED50 for this effect is less than 0.1 ng/mL.
Storage Buffer
Lyophilized from 0.5X PBS, pH 7.5
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with sterilized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing.Note
Result of activity analysis
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Applications
Functional Study
SDS-PAGE
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Gene Info — FGF4
Entrez GeneID
2249Protein Accession#
P08620Gene Name
FGF4
Gene Alias
HBGF-4, HST, HST-1, HSTF1, K-FGF, KFGF
Gene Description
fibroblast growth factor 4
Omim ID
164980Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq
Other Designations
heparin secretory transforming protein 1|human stomach cancer, transforming factor from FGF-related oncogene|kaposi sarcoma oncogene|oncogene HST|transforming protein KS3
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Interactome
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Pathway
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Disease
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