ARTN (Human) Recombinant Protein

Catalog # P4372

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Price

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Quantity

Size:20 ug
Price: USD $ 288.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
QC Test

Lane 1: non-reducing conditions
Lane 2: reducing conditions

  • Specification

    Product Description

    Human ARTN (Q5T4W7) recombinant protein expressed in Escherichia coli.Bioactive Protein,Bioactive Proteins,Bioactive,Active,Functional Protein,Functional Proteins

    Sequence

    AGGPGSRARAAGARGCRLRSQLVPVRALGLGHRSDELVRFRFCSGSCRRARSPHDLSLASLLGAGALRPPPGSRPVSQPCCRPTRYEAVSFMDVNSTWRTVDRLSATACGCLG

    Host

    Escherichia coli

    Theoretical MW (kDa)

    24.2

    Form

    Lyophilized

    Preparation Method

    Escherichia coli expression system

    Endotoxin Level

    < 0.1 EU/ug

    Activity

    The activity is determined by the dose-dependant proliferation of the SH-SY5Y cell line and is typically 4-8 ng/mL. The activity can also determined by the ability to promote survival and neurite outgrowth.

    Quality Control Testing

    1 ug/lane in 4-20% Tris-Glycine gel Stained with Coomassie Blue

    Lane 1: non-reducing conditions
    Lane 2: reducing conditions

    Storage Buffer

    Lyophilized from 10 mM sodium citrate, 25 mM NaCl, pH 4.5

    Storage Instruction

    Store at -20°C on dry atmosphere.
    After reconstitution with sterilized water, store at -20°C or lower.
    Aliquot to avoid repeated freezing and thawing.

  • Applications

    Functional Study

    Functional Study

    SDS-PAGE

    SDS-PAGE

  • Gene Info — ARTN

    Entrez GeneID

    9048

    Protein Accession#

    Q5T4W7

    Gene Name

    ARTN

    Gene Alias

    ENOVIN, EVN, NBN

    Gene Description

    artemin

    Omim ID

    603886

    Gene Ontology

    Hyperlink

    Gene Summary

    The protein encoded by this gene is a member of the glial cell line-derived neurotophic factor (GDNF) family of ligands which are a group of ligands within the TGF-beta superfamily of signaling molecules. GDNFs are unique in having neurotrophic properties and have potential use for gene therapy in neurodegenerative disease. Artemin has been shown in culture to support the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. Its role in the PNS and CNS is further substantiated by its expression pattern in the proximity of these neurons. This protein is a ligand for the RET receptor and uses GFR-alpha 3 as a coreceptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

    Other Designations

    OTTHUMP00000009173|OTTHUMP00000009174|neublastin|neurotrophic factor|neurotrophic factor artemin

  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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